Batting first, South Australia made a modest 202 before being bowled out in 44.5 overs.
Leg-spinner Tom O'Connell top-scored with 37 runs batting at no.5, while Lucas Froude also contributed a handy 30.
Bailey Capel opened the batting with an emphatic 29 off 24, including six boundaries, but SA would come to lament the lack of a lasting partnership.
There were an even spread of wicket-takers for Queensland, with Harrison Wood the pick of the bowlers with 2-11.
Queensland chased down their target inside 32 overs, through an undefeated partnership between openers Angus Lovell and Max Bryant.
SA next play the CA XI on Sunday.