Captain Megan Schutt remains in the 13-player squad before assuming national duties for the CommBank T20I Tri-Series against India and England, in preparation for the ICC T20 World Cup.
Schutt has been at her best, taking seven wickets at an average of 7.71 from her two WNCL appearances this season.
Yet to post a win in the 2019-20 season, the Scorpions will be desperately hunting victory against an in-form Western Australia side.
South Australia lose New Zealand international Suzie Bates, with pace-bowler Stacey Oates replacing Bates in the squad.
WA is expected to be without their star import, the dangerous Sophie Devine, who compiled a match-winning century in the last round of games against Victoria.
Scorpions opener, Bridget Patterson, leads the pack for runs with 234 from four matches at an average of 78, while fellow opener Tahlia McGrath has also been striking the ball well.
Bowler and middle-order batter Sam Betts posted her maiden WNCL half-century in the last match and will be hoping her batting form continues.
Both matches will be played at the WACA and begin at 12:30pm Adelaide time.
Statewide Super SA Scorpions 13-player squad v WA
Megan Schutt (c), Tahlia McGrath, Sam Betts, Darcie Brown, Emma de Broughe, Eliza Doddridge, Ellie Falconer, Tegan McPharlin, Stacey Oates, Annie O’Neil, Bridget Patterson, Alex Price, Amanda-Jade Wellington.
Round 5 & 6 fixture
Tuesday 21 January, WA v SA, The WACA, 12:30pm ACDT
Thursday 23 January, WA v SA, The WACA, 12:30pm ACDT
Live scores can be followed on cricket.com.au and the CA Live App. Regular updates will also be provided on Twitter at @ScorpionsSA.