After serving as 12th man for the opening Magellan Ashes Test in Brisbane, Sayers was again overlooked for a dream home debut at Adelaide Oval against England.
Ferguson conceded it was “bittersweet” news for the South Australian squad, with Sayers cleared to join his teammates in Cairns for Sunday’s JLT Sheffield Shield clash with Queensland.
Ferguson expected the 30-year-old to come out firing against the Bulls.
“He certainly comes back disappointed as you can imagine, but it (only) makes him hungrier generally,” Ferguson said.
“If you look back at his last couple of years he hasn’t had too many down games so I’m expecting nothing different.
“He’s a super professional and he’ll be looking to bounce back and prove a few people wrong.”
Sayers and fellow fast bowler Joe Mennie will both play their 50th Sheffield Shield game for the Redbacks this week.
The milestone duo will need to be at their best with quicks Kane Richardson and Daniel Worrall sidelined by injury.
Ferguson said the tropical humidity of Cairns could suit the pair with temperatures forecast above 30 degrees forecast through all four days of scheduled play.
“Generally, it’s a little bit humid so the ball can swing around a little bit,” Ferguson said.
“When you get to these types of ground where there’s not a lot of first-class cricket played, the curators are generally pretty conservative so it rolls out pretty flat and it can tend to break up a bit late because they keep it a bit dry.
“He’ll (Sayers) give us a big boost in the bowling department and I think he’ll enjoy the humidity up here.”
South Australia sits fourth on the Shield table after a disappointing loss to Tasmania last round while Queensland holds second spot just one win shy of ladder leaders New South Wales.
The series will break for BBL|07 following this week’s matches with Shield action resuming in early February.
“It’s going to be a big game for us coming off not our best week last week,” Ferguson said.
“We’ll make sure we go out there all guns blazing on day one.”
Play begins at 10:00am local (10:30am ACDT) on Sunday, 3 December at Cazaly’s Stadium in Cairns. A live stream and scores will be available via cricket.com.au and the Cricket Australia Live app.