Ferguson will play his 124th match with 8210 runs under his belt when the two teams take the field at ACH Group Stadium in Glenelg.
The 35-year-old bows out of the Sheffield Shield as the second-most capped for South Australia, and fifth on the all-time runscorers tally.
Left-hand batsman Jake Lehmann has been brought into the 15-player squad for the first time this season.
Head Coach Jason Gillespie said:
“Firstly, we wish Callum the very best in his final first-class game after such an exceptional career at the highest level.
“He has been a fine servant of the State and his influence on this playing group will remain for years to come.
“We also welcome Jake into the squad who has been a leader around the broader Redbacks group to the high standard we expect.”
The Redbacks last played out a defiant draw against Victoria, which saw them bat through 160 overs to save the game.
Play begins at 10:30am on Sunday, and the playing XI will be announced at the toss.
South Austalia’s 15-player squad
Travis Head (c)
In: Jake Lehmann
Out: Brad Davis (omitted)