The 24-year-old starred with career-best figures of 6/40 from 24 overs, which included nine maidens, in his first Shield outing of the season.
Test-capped batsmen Joe Burns (11) and Marnus Labuschagne (36) were among his victims as the Redbacks bowled out the Bulls for 115 by Tea at the Gabba.
Pace trio Nick Winter (1/30), Joe Mennie (1/18) and Luke Robins (1/17) all chipped in after being sent into the field by the hosts.
But South Australia has work to do despite Andrews’ brilliance with the ball.
A total of 17 wickets fell on a green-tinged Gabba pitch as SA stumbled to 7/67 before bad light brought an early end to the first day of play.
Jake Lehmann, returning to his post at No.5 in the order, will resume on 23* alongside Nick Winter (1*) with the visitors trailing by 48 runs.
Redbacks debutant Brad Davis was presented Baggy Red No.637 by former Test batsman Greg Blewett and was involved all day, claiming two sharp catches at point and contributing to a run out of Cameron Gannon for a duck.
He then scored 16 off 20 deliveries before Gannon exacted revenge with the ball.
Play will resume at the earlier time of 9:30am local (10:00am ACDT) on Tuesday to recoup lost overs.
Bad light brings an early end to play— West End Redbacks (@WestEndRedbacks) March 11, 2019
17 wickets fall on Day One. Lehmann 23* will resume with Winter 1* tomorrow
SA 7/67 trail by 48
Scorecard 📊: https://t.co/R3d1JA0Os5 #SheffieldShield #QLDvSA pic.twitter.com/AfN5eoxOz6