Nathan Lyon helped the hosts turn the screws on Pakistan’s middle and lower order with five key wickets to have the tourists all out for 239 early in the final session of day four of the day-night Test.
The 32-year-old off-spinner has now taken 50 Test wickets at Adelaide Oval, second only to Australian Shane Warne (56) at the venue.
Josh Hazlewood chimed in with three wickets, while paceman Mitchell Starc added one to his first-innings figures of 6/66.
Pakistan showed fight with half-centuries to Pakistan opener Shan Masood (68 from 127 balls) and Asad Shafiq (57 from 112) but it only delayed the impending Australian victory.
Australia has now won six of the seven Tests played at Adelaide Oval since the drop-in pitches were introduced before the 2013/14 season.
The 78th Test match at Adelaide Oval will be most remembered for the record-breaking performance of Australian opener David Warner, who scored the first Test triple century at the ground. Warner passed the previous record of 299 not out made by Don Bradman in 1932 on the way to his 335 not out.
He also shared a second wicket stand of 361 runs with Marnus Labuschagne (162), a record for both the second wicket in Australia and any Australian partnership against Pakistan.
Babar Azam’s brilliant 97 thrilled the Adelaide Oval fans but Yasir Shah’s maiden century was the highlight of Pakistan’s first innings after its top order struggled against Starc, with his 6/66 a career-best.
A crowd of 10,052 on the final day at Adelaide Oval lifted the total attendance to 91,879 in the return of day-night Test cricket to the venue.
The home side will prepare for a three-Test series against an in-form New Zealand beginning on 12 December in Perth.