Warner 166* and Labuschagne 126* took charge after Australia won the toss and elected to bat in overcast conditions. Rain delayed play during the afternoon but a crowd of 30,878 still came through the gates in the return of day-night Test cricket to Adelaide.
It was Warner’s fourth Test ton at Adelaide Oval, joining David Boon and Allan Border on the leaderboard behind only Michael Clarke (seven) and Ricky Ponting (six).
Labuschagne’s innings backed up an impressive 185 in the first Test at the Gabba as the pair put on 294 runs – the highest second-wicket partnership in Test matches between the two countries.
Teenage quick Shaheen Afridi claimed Pakistan’s sole wicket of Joe Burns (4) inside the first four overs but it was an otherwise challenging day for the tourists.
Australia will resume at 1/302 on Saturday at Adelaide Oval.
Play will begin at the earlier time of 1:30pm local. Gates open at 12pm.
Meanwhile, West End Redbacks pair Joe Mennie and Chadd Sayers claimed two wickets apiece to have Western Australia 5/296 at stumps on the first day of Marsh Sheffield Shield action at the WACA.